The Tonight Show with Jimmy Fallon features multiple musical performances and guest appearances, including Angine de Poitrine's U.S. television debut with their new song 'Zugzegk,' Don Toliver performing an 'OCTANE' medley ahead of his album release, and a cover of Ella Langley's 'Choosin' Texas' by Matthew McConaughey and Fallon. Other highlights include KATSEYE's late-night performance debut, surprise guests Charlie Puth, Busta Rhymes, and Art Garfunkel at a Madison Square Garden concert, and recurring comedic moments involving Matty Matheson and joke-sharing references.